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监测微小残留病MRD在儿童急性淋巴细
文章来源：急性白血病 发布时间:2016-11-3 12:52:33 点击数： 次
Monitoringminimalresidualdiseaseinchildrenwithhigh-riskrelapsesofacutelymphoblasticleukemia:prognosticrelevanceofearlyandlateassessment
摘要原文Theprognosisforchildrenwithhigh-riskrelapsedacutelymphoblasticleukemia(ALL)ispoor.Here,weassessedtheprognosticimportanceofresponseduringinductionandconsolidationtreatmentpriortohematopoieticstemcelltransplantation(HSCT)aimingtoevaluatethebesttimetoassessminimalresidualdisease(MRD)forinterventionstrategiesandinfuturetrialsinhigh-riskALLrelapsepatients.Includedpatients(n=)weretreateduniformlyaccordingtotheALL-REZBFM(Berlin-Frankfurt-Münster)relapsetrial(medianfollow-uptime=4.8years).PatientswithMRD≥10?3afterinductiontreatment(76/,64%)orimmediatelyprecedingHSCT(19/71,27%)hadasignificantlyworseprobabilityofdisease-freesurvival10yearsafterrelapsetreatmentbegin,with26%(±6%)or23%(±7%),respectively,北京专治男性白癜风的医院北京哪个医院专业治疗白癜风
